THE FOUNDATION FOR PREVENTIVE ONCOLOGY, INC.
Institute for Hormone Research, Institute for and Nutrition

THE CANCER AND NUTRITION NETWORK
"Nourishing mind, body, and spirit

Welcome,

The purpose of this site is to help you understand the vital links between cancer and nutrition. We offer you this information through our Foundation's "Network Seminar Program."

A "seminar" is a "seed bed" for ideas, an intellectual space where your understanding of nutrition as nourishment – nourishment not only for the body, but for your mind and your spirit.

We call our first Seminar "Nourishing Your Health: Breast Cancer, Nutrition, and Your Spiritual Life." "Nourishing Your Health" is a personal, evolving, learning experience, not merely a printer-ready collection of nutritional facts. If you are at risk for breast cancer; if you are facing a breast cancer diagnosis; if you are undergoing treatment; if you are a breast cancer survivor; if you fall into any of these groups, you may find "Nourishing Your Health" a valuable, informational tool.

"Nourishing Your Health" is an on-line educational resource that a medical consultation program. Its goal is to enrich your dialogue with your physician. It is to complement not substitute that vital personal interchange.

This Seminar has been created to give you access to the best information available concerning the relationship between breast cancer, estrogen metabolism, and nutrition. It endeavors to explain the "Why?" behind the dietary recommendations you hear almost at every turn. It offers no nutritional panaceas, no miracle cures. What "Nourishing Your Health" does offer is an understanding of the healing potential of the foods we eat every day – miracle enough, we believe, for us all.

"Nourishing Your Health" is structured as a series of lessons, exercises, and reflections addressing your physical, intelectual, and spiritual needs. It has been designed for the woman who is not content with media sound-bites, for that individual who knows that her encounter with breast cancer demands more than dietary change alone. "Nourishing Your Health" provides "information as nutrition" to help meet the demands of this encounter.

If breast cancer is a fact or a fear in your life, I invite you to take your place at our seminar table.

Wishing you health and wholeness,

Jon J. Michnovicz, M.D., Ph.D.
President and Medical Director


Seminars

"Nourishing Your Health" is our Network response to the many questions you may have about the relationship between nutrition and breast cancer. When you take your place at our seminar table, you will have access to the following:

1. Critical information about the relationship between nutrition and breast cancer.

2. Reviews of pertinent articles on breast cancer and nutrition from major peer- reviewed medical journals.

3. Guidelines for making specific dietary changes in your life.

4. A program for making theses changes an integral, complementary dimension of your breast - healthy nutrition regimen.

5. "The power of 10, " a seven-day meal plan.

6. 50 convenient recipes.

7. Spiritual readings and responses.

8. Our "Internet Forum" where you will discover the answers to frequently asked questions about breast health and nutrition




THE FOUNDATION FOR PREVENTIVE ONCOLOGY, INC.

We are an independent, not-for-profit foundation dedicated to the prevention of cancer in the abled and disabled communities by promoting a deeper understanding of the relationship between cancer, hormone metabolism, and nutritional health.

The Foundation for Preventive Oncology, Inc. is an alliance of physicians, educators, researchers, and health professionals dedicated to the advancement of preventive oncology – the new field of cancer prevention.

The Foundation conducts its scientific studies through the Institute for Hormone Research, its biomedical research arm. The focus of this research is the role of steroid hormones in the causation and prevention of cancer.

The Foundation's investigations into the physiology and metabolism of steroid hormones through the lnstitute for Hormone Research have come to fruition in a series of clinical research initiatives in the area of chemoprevention. Institute researchers have made the discovery that certain naturally occurring substances in fruits and vegetables have the capacity to modulate hormone metabolism in humans. The discovery has important implications for the prevention of disease, especially in the prevention of breast, prostate, and colon cancer.

The Institute for Cancer and Nutrition is the Foundation's community service and educational arm. The Institute provides direct medical and medical nutritional services to the physically and developmentally disabled and nutritional chemopreventive information to the world at large through the Cancer and Nutrition Network. The Cancer and Nutrition Network offers internet seminars to individuals seeking a better understanding of the vital links between nutritional health, cancer, and spirituality.

The Foundation and its Institutes have collaborated closely with many national and international institutions. Among these noted medical and academic centers are The Rockefeller University; New York University Medical Center; Memorial Sloan-Kettering Cancer Center, Mount Sinai Medical Center; Cabrini Medical Center; Dartmouth Medical School; Washington University Medical Center; the Meilahti Hospital, Finland; Tohoku University, Japan; and the Chinese Academy of Medicine in Beijing.

The Foundation's research has been reported on The CBS Evening News with Dan Rather, CBS This Morning with Dr. Bob Arnot, NBC News Live at Five, Fox News Network, The MacNeil/Lehrer PBS production "Eat Smart," CNN, Lifetime, America's Talking, The TV Food Network, GLOBO International TV Brazil, and other cable network programs.

Articles discussing Foundation research have appeared in Reader's Digest, Prevention, Self, Ladies Home Journal, Redbook, Glamour, McCall's, Science News, and the CSPI Nutrition Action Health Letter. In July 1994, Warner Books published How to Reduce Your Risk of Breast Cancer by Dr. Michnovicz and his co-author Diane S. Klein. This well received work was a selection of the Book-of-the-Month Club, Quality Paperback Book Club, and Prevention Book Club.

The Foundation's Network Seminar Program draws upon the discoveries of modern science and the age-old wisdom of the world's spiritual traditions to convey its message of hope and healing.



PRESIDENT AMD MEDICAL DIRECTOR

John Michnovicz, M.D., Ph.D. has dedicated his career as both a physician and biomedical researcher to preventive and developmental medicine. As the president of The Foundation for Preventive Oncology, Inc. and the Medical Director of both the Institute for Harmone Research and Institute for Cancer and Nutrition, Dr. Michnovicz supervises and conducts new studies into the interactions of diet, lifestyle, hormones and cancer. Dr. Michnovicz is Director of the Medical Nutrition Program at Premier HealthCare of the YA/National Institute for people with Disabilities.

Dr. Michnovicz is a member of the American Society for Preventive Oncology, the American Institute of Nutrition, and the American Society for Clinical Nutrition. He has authored more than 50 scientific articles and abstractions in the field of nutrition chemoprevention. The results of his research have twice been published in the prestigous New England Journal of Medicine and have won international recognition.

Dr. Michnovicz sits on numerous governmental committies and medical research study sections. He has served as Chairman of the Clinical and Therapeutics Section of the United States Army Breast Cancer Research Project and as Chairman of the Clinical Health Studies Section of the Army's Prostate Cancer Research Program. Dr. Michnovicz has been a Member of the Special Review Committee of the diet and Cancer Branch of the National Cancer Institute. In 2000, Dr. Michnovicz was called upon to determine the recipients of the National Cancer Institute's "Insight Awards to Stamp Out Breast Cancer."

Dr. Michnovicz is Adjunct Assistant Professor, Department of Medicine at New York University Medical Center and Attending Physician at Cabrini Medical Center.

PUBLICATIONS:

Journal Articles

The Foundation for Preventive Oncology, Inc./Institute for Hormone Research has
published extensively in the field of breast cancer, nutrition, and estrogen metabolism.
These peer-reviewed journal articles are listed below:

Michnovicz, J.J., Hershcopf, R.J., Naganuma, H., Bradlow, H.L. and Fishman, J. Increased 2-
hydroxylation of estradiol as a possible mechanism for the antiestrogenic effect of cigarette
smoking. N. Engl. J. Med. 315:1305-1309, 1986.

Michnovicz, J.J. Environmental modulation of estrogen metabolism in humans. Int. Clin. Nutr.
Rev
. 7:169-173,1987.
Naganuma, H., Hershcopf, R.J., Michnovicz, J.J., Miyairi, S., Bradlow, H.L. and Fishman, J.
Radioimmunoassay of 16α-hydroxyestrone in human urine. Steroids. 53:37-48, 1989.

Galbraith, R.A. and Michnovicz, J.J. The effects of cimetidine on the oxidative metabolism of
estradiol. N. Engl. J. Med. 321:269-274,1989.

Bradlow, H.L. and Michnovicz, J.J. A new approach to the prevention of breast cancer. Proc. R.
Soc. Edin.
95B:77-86,1989.

Michnovicz, J.J. and Galbraith, R.A. Effects of exogenous thyroxine on C-2 and C-16α
hydroxylations of estradiol in humans. Steroids. 55:22-26, 1990.

Michnovicz, J.J. and Bradlow, H.L. Dietary and pharmacological control of estradiol
metabolism in humans. Ann. N.Y. Acad Sci. 595:291-299, 1990.

Michnovicz, J.J. and Bradlow, H.L. Introduction of estradiol metabolism by dietary indole-3-
carbinol. Journal of the National Cancer Institute. 82:947-949, 1990.

Michnovicz, J.J. and Bradlow, H.L. Altered estrogen metabolism and excretion in humans
following consumption of indole-3-carbinol. Nutrition and Cancer. 16:59-66, 1991.

Bradlow, H.L.,Michnovicz, J.J., Telang, N.T. and Osborne, M.P. Effects of indole-3-carbinol
on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis. 12:1571-
1574, 1991.

Jellinck, P.H., Michnovicz, J.J. and Bradlow, H.L. Influence of indole-3-carbinol on the hepatic
microsomal formation of catechol estrogens. Steroids. 56:446-450, 1991.

Bradlow, H.L., Telang, N.T., Osborne, M.P. and Michnovicz, J.J. Selective induction of
cytochrome P-450 enzymes in the prevention of breast cancer. In: The New Biology of Steroid
Hormones
. Hochberg, R.B. and Naftolin, R. (eds). Serono Symposium Proceedings. Vol. 74,
pp. 125-144, 1991.

Bradlow, H.L., Michnovicz, J.J., Telang, N.T., Osborne,M.P. and Goldin, B.R. Diet,
oncogenes, and tumor viruses as modulators of estrogen metabolism in vivo and in vitro. Cancer
Detection and Prevention. 16(Suppl):S35-S42, 1992.

Bradlow, H.L, Osborne, M.P.,Michnovicz, J.J. and Telang, N. T. Modulation of estrogen
metabolism by inducers of P450IA2:possible application to the chemoprevention of breast
cancer. In: Hormonal Carcinogenesis: Proceedings of the First International Symposium. Li,
J.J., Nandi, S. and Li, S.A. (eds). Springer- Verlag, New York. pp. 296-299, 1992.

Jellinck, P.H., Michnovicz, J.J. and Bradlow, H.L. Induction of catechol estrogen formation by
indole-3-carbinol. In: Hormonal Carcinogenesis: Proceedings of the First International
Symposium. Li, J.J., Nandi, S. and Li, S.A. (eds). Springer-Verlag, New York. pp 296-299,
1992.

Jellinck, P.H., Forkert, P.G., Riddick, D.S., Okey, A.B., Michnovicz, J.J. and Bradlow, H.L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
Biochemical Pharmacology. 45:1129-1136, 1993.

Bradlow, H.L., Telang, N.T., Michnovicz, J.J. and Osborne, M.P. Diet and breast cancer. In:
Food and cancer Prevention: Chemical and Biological Aspects. Waldron, K.W., Johnson, I.T.
and Fenwick, G.R. (eds). The Royal Society of Chemistry, Cambridge. pp. 270-274, 1993.

Michnovicz, J.J. and Bradlow, H.L. Dietary cytochrome P-450 modifiers in the control of
estrogen metabolism. In: Food Phytochemicals and Cancer Prevention, Huang, M-T., Oswawa,
T.,Ho, C-T. and Rosen, R.T. (eds). American Chemical Society Symposium Series, #546. pp.
282-293, 19994.

Sepkovic, D.W., Bradlow H.L., Michnovicz, J.J., Murtezani, S., Levy, I. and Osborne, M.P.
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol,
ascorbigen, or β-naphthaflavone: A comparison of stable isotope dilution gas chromatography-
mass spectrometry and radiometric methods. Steriods. 59:318-323, 1994.

Bradlow, H.L., Michnovicz, J.J., Halper, M., Miller, D.G., Wong, G.Y.C., Osborne, M.P. Long- term responses of women to indole-3-carbonol or a high fiber diet. Cancer Epidemiology,
Biomarkers & Prevention.
3:591-595, 1994.

Michnovicz, J.J. Plant estrogens and human health. Annals of Surgical Oncology. 3(6):513-
514, 1996.

Michnovicz, J.J. Adlercreutz, H., Bradlow, H.L. Changes in levels of urinary estrogen
metabolites afer oral indole-3-carbinol treatment in humans. Journal of the national Cancer
Institute.
89(10):718-723, 1997.

Michnovicz, J.J. Increased estrogen 2-hydroxylation in obese women using oral indole-3-
carbonal. International Journal of Obesity. 22:227-229, 1998.