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Journal Articles
The Foundation for Preventive Oncology, Inc./Institute for Hormone Research has
published extensively in the field of breast cancer, nutrition, and estrogen metabolism.
These peer-reviewed journal articles are listed below:
Michnovicz, J.J., Hershcopf, R.J., Naganuma, H., Bradlow, H.L. and Fishman, J. Increased 2-
hydroxylation of estradiol as a possible mechanism for the antiestrogenic effect of cigarette
smoking. N. Engl. J. Med. 315:1305-1309, 1986.
Michnovicz, J.J. Environmental modulation of estrogen metabolism in humans. Int. Clin. Nutr.
Rev. 7:169-173,1987.
Naganuma, H., Hershcopf, R.J., Michnovicz, J.J., Miyairi, S., Bradlow, H.L. and Fishman, J.
Radioimmunoassay of 16α-hydroxyestrone in human urine. Steroids. 53:37-48, 1989.
Galbraith, R.A. and Michnovicz, J.J. The effects of cimetidine on the oxidative metabolism of
estradiol. N. Engl. J. Med. 321:269-274,1989.
Bradlow, H.L. and Michnovicz, J.J. A new approach to the prevention of breast cancer. Proc. R.
Soc. Edin. 95B:77-86,1989.
Michnovicz, J.J. and Galbraith, R.A. Effects of exogenous thyroxine on C-2 and C-16α
hydroxylations of estradiol in humans. Steroids. 55:22-26, 1990.
Michnovicz, J.J. and Bradlow, H.L. Dietary and pharmacological control of estradiol
metabolism in humans. Ann. N.Y. Acad Sci. 595:291-299, 1990.
Michnovicz, J.J. and Bradlow, H.L. Introduction of estradiol metabolism by dietary indole-3-
carbinol. Journal of the National Cancer Institute. 82:947-949, 1990.
Michnovicz, J.J. and Bradlow, H.L. Altered estrogen metabolism and excretion in humans
following consumption of indole-3-carbinol. Nutrition and Cancer. 16:59-66, 1991.
Bradlow, H.L.,Michnovicz, J.J., Telang, N.T. and Osborne, M.P. Effects of indole-3-carbinol
on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis. 12:1571-
1574, 1991.
Jellinck, P.H., Michnovicz, J.J. and Bradlow, H.L. Influence of indole-3-carbinol on the hepatic
microsomal formation of catechol estrogens. Steroids. 56:446-450, 1991.
Bradlow, H.L., Telang, N.T., Osborne, M.P. and Michnovicz, J.J. Selective induction of
cytochrome P-450 enzymes in the prevention of breast cancer. In: The New Biology of Steroid
Hormones. Hochberg, R.B. and Naftolin, R. (eds). Serono Symposium Proceedings. Vol. 74,
pp. 125-144, 1991.
Bradlow, H.L., Michnovicz, J.J., Telang, N.T., Osborne,M.P. and Goldin, B.R. Diet,
oncogenes, and tumor viruses as modulators of estrogen metabolism in vivo and in vitro. Cancer
Detection and Prevention. 16(Suppl):S35-S42, 1992.
Bradlow, H.L, Osborne, M.P.,Michnovicz, J.J. and Telang, N. T. Modulation of estrogen
metabolism by inducers of P450IA2:possible application to the chemoprevention of breast
cancer. In: Hormonal Carcinogenesis: Proceedings of the First International Symposium. Li,
J.J., Nandi, S. and Li, S.A. (eds). Springer- Verlag, New York. pp. 296-299, 1992.
Jellinck, P.H., Michnovicz, J.J. and Bradlow, H.L. Induction of catechol estrogen formation by
indole-3-carbinol. In: Hormonal Carcinogenesis: Proceedings of the First International
Symposium. Li, J.J., Nandi, S. and Li, S.A. (eds). Springer-Verlag, New York. pp 296-299,
1992.
Jellinck, P.H., Forkert, P.G., Riddick, D.S., Okey, A.B., Michnovicz, J.J. and Bradlow, H.L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
Biochemical Pharmacology. 45:1129-1136, 1993.
Bradlow, H.L., Telang, N.T., Michnovicz, J.J. and Osborne, M.P. Diet and breast cancer. In:
Food and cancer Prevention: Chemical and Biological Aspects. Waldron, K.W., Johnson, I.T.
and Fenwick, G.R. (eds). The Royal Society of Chemistry, Cambridge. pp. 270-274, 1993.
Michnovicz, J.J. and Bradlow, H.L. Dietary cytochrome P-450 modifiers in the control of
estrogen metabolism. In: Food Phytochemicals and Cancer Prevention, Huang, M-T., Oswawa,
T.,Ho, C-T. and Rosen, R.T. (eds). American Chemical Society Symposium Series, #546. pp.
282-293, 19994.
Sepkovic, D.W., Bradlow H.L., Michnovicz, J.J., Murtezani, S., Levy, I. and Osborne, M.P.
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol,
ascorbigen, or β-naphthaflavone: A comparison of stable isotope dilution gas chromatography-
mass spectrometry and radiometric methods. Steriods. 59:318-323, 1994.
Bradlow, H.L., Michnovicz, J.J., Halper, M., Miller, D.G., Wong, G.Y.C., Osborne, M.P. Long- term responses of women to indole-3-carbonol or a high fiber diet. Cancer Epidemiology,
Biomarkers & Prevention. 3:591-595, 1994.
Michnovicz, J.J. Plant estrogens and human health. Annals of Surgical Oncology. 3(6):513-
514, 1996.
Michnovicz, J.J. Adlercreutz, H., Bradlow, H.L. Changes in levels of urinary estrogen
metabolites afer oral indole-3-carbinol treatment in humans. Journal of the national Cancer
Institute. 89(10):718-723, 1997.
Michnovicz, J.J. Increased estrogen 2-hydroxylation in obese women using oral indole-3-
carbonal. International Journal of Obesity. 22:227-229, 1998.
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