The Cancer and Nutrition Network
"Nourishing mind, body and spirit" 

The Foundation for Preventive Oncology, Inc./Institute for Hormone Research has
published extensively in the field of breast cancer, nutrition, and estrogen metabolism.
Books and peer-reviewed journal articles are listed below:

Books

Michnovicz, J. J., Klein, Diane S. How to Reduce Your Risk of Breast Cancer. Warner Books. 1994. [image]

Over 50,000 copies sold in three languages!

Journal Articles

The Foundation for Preventive Oncology, Inc./Institute for Hormone Research has
published extensively in the field of breast cancer, nutrition, and estrogen metabolism.
Peer-reviewed journal articles are listed below:

Michnovicz, J. J., Hershcopf, R.J., Naganuma, H., Bradlow, H. L. and Fishman, J. Increased 2-
hydroxylation of estradiol as a possible mechanism for the antiestrogenic effect of cigarette
smoking. N. Engl. J. Med. 315:1305-1309, 1986.

Michnovicz, J. J. Environmental modulation of estrogen metabolism in humans. Int. Clin. Nutr.
Rev. 7:169-173,1987.

Naganuma, H., Hershcopf, R.J., Michnovicz, J. J., Miyairi, S., Bradlow, H. L. and Fishman, J.
Radioimmunoassay of 16α-hydroxyestrone in human urine. Steroids. 53:37-48, 1989.

Galbraith, R. A. and Michnovicz, J. J. The effects of cimetidine on the oxidative metabolism of
estradiol. N. Engl. J. Med. 321:269-274,1989.

Bradlow, H. L. and Michnovicz, J. J. A new approach to the prevention of breast cancer. Proc. R.
Soc.  Edinb. 95B:77-86,1989.

Michnovicz, J. J. and Galbraith, R. A. Effects of exogenous thyroxine on C-2 and C-16α
hydroxylations of estradiol in humans. Steroids. 55:22-26, 1990.

Michnovicz, J. J. and Bradlow, H. L. Dietary and pharmacological control of estradiol
metabolism in humans. Ann. N.Y. Acad. Sciences 595:291-299, 1990.

Michnovicz, J. J. and Bradlow, H. L. Introduction of estradiol metabolism by dietary indole-3-carbinol.  Journal of the National Cancer Institute. 82:947-949, 1990.

Michnovicz, J. J. and Bradlow, H. L. Altered estrogen metabolism and excretion in humans
following consumption of indole-3-carbinol. Nutrition and Cancer. 16:59-66, 1991.

Bradlow, H. L., Michnovicz, J. J., Telang, N. T. and Osborne, M. P. Effects of indole-3-carbinol
on estradiol metabolism and spontaneous mammary tumors in mice. Carcinogenesis. 12:1571-
1574, 1991.

Jellinck, P. H., Michnovicz, J. J. and Bradlow, H. L. Influence of indole-3-carbinol on the hepatic
microsomal formation of catechol estrogens. Steroids. 56:446-450, 1991.

Bradlow, H. L., Telang, N. T., Osborne, M. P. and Michnovicz, J. J. Selective induction of
cytochrome P-450 enzymes in the prevention of breast cancer. In: The New Biology of Steroid
Hormones. Hochberg, R. B. and Naftolin, R. (eds). Serono Symposium Proceedings. Vol. 74,
pp. 125-144, 1991.

Bradlow, H. L., Michnovicz, J. J., Telang, N. T., Osborne, M. P. and Goldin, B. R. Diet,
oncogenes, and tumor viruses as modulators of estrogen metabolism in vivo and in vitro. Cancer
Detection and Prevention. 16(Suppl):S35-S42, 1992.

Bradlow, H. L, Osborne, M. P., Michnovicz, J. J. and Telang, N. T. Modulation of estrogen
metabolism by inducers of P450IA2: possible application to the chemoprevention of breast
cancer. In: Hormonal Carcinogenesis: Proceedings of the First International Symposium. Li,
J. J., Nandi, S. and Li, S. A. (eds). Springer- Verlag, New York. pp. 296-299, 1992.

Jellinck, P. H., Michnovicz, J. J. and Bradlow, H. L. Induction of catechol estrogen formation by
indole-3-carbinol. In: Hormonal Carcinogenesis: Proceedings of the First International
Symposium. Li, J. J., Nandi, S. and Li, S. A. (eds). Springer-Verlag, New York. pp 296-299,
1992.

Jellinck, P. H., Forkert, P. G., Riddick, D.S., Okey, A. B., Michnovicz, J. J. and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation.
Biochemical Pharmacology. 45:1129-1136, 1993.

Bradlow, H. L., Telang, N. T., Michnovicz, J. J. and Osborne, M. P. Diet and breast cancer. In:
Food and cancer Prevention: Chemical and Biological Aspects. Waldron, K. W., Johnson, I. T.
and Fenwick, G. R. (eds). The Royal Society of Chemistry, Cambridge. pp. 270-274, 1993.

Michnovicz, J. J. and Bradlow, H. L. Dietary cytochrome P-450 modifiers in the control of
estrogen metabolism. In: Food Phytochemicals and Cancer Prevention, Huang, M-T., Oswawa,
T., Ho, C-T. and Rosen, R. T. (eds). American Chemical Society Symposium Series, #546. pp.
282-293, 19994.

Sepkovic, D. W., Bradlow H. L., Michnovicz, J. J., Murtezani, S., Levy, I. and Osborne, M. P.
Catechol estrogen production in rat microsomes after treatment with indole-3-carbinol,
ascorbigen, or β-naphthaflavone: A comparison of stable isotope dilution gas chromatography-
mass spectrometry and radiometric methods. Steroids. 59:318-323, 1994.

Bradlow, H. L., Michnovicz, J. J., Halper, M., Miller, D. G., Wong, G. Y. C., Osborne, M. P. Long- term responses of women to indole-3-carbonol or a high fiber diet. Cancer Epidemiology,
Biomarkers & Prevention. 3:591-595, 1994.

Michnovicz, J. J. Plant estrogens and human health. Annals of Surgical Oncology. 3(6):513-
514, 1996.

Michnovicz, J. J. Adlercreutz, H., Bradlow, H. L. Changes in levels of urinary estrogen
metabolites after oral indole-3-carbinol treatment in humans. Journal of the national Cancer
Institute. 89(10):718-723, 1997.

Michnovicz, J. J. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. International Journal of Obesity. 22:227-229, 1998.